FOUNDATIONAL TERM
cellular senescence
细胞衰老
A state of relatively stable cell-cycle arrest with continuing metabolic activity.
Study this concept in context
96 · Ageing: cells, organs and individual variation
Ageing involves long-term changes in molecular damage, cellular responses, and organ reserve. Age alone cannot specify ability or disease. Mechanisms help explain variation and evaluate research without turning laboratory measures into promises of rejuvenation.
Sources
- WHO: Ageing and health
- López-Otín et al.: Hallmarks of aging, 2023
- NIH Common Fund: Cellular Senescence Network
- NHGRI: Telomere
- NIA: A bright future for aging biology research
- NIA: DNA changes and health outcomes in older adults
Definitions come from the published lessons. Read the linked lesson for mechanisms, conditions and examples.