FOUNDATIONAL TERM
penetrance
外显率
The proportion of people carrying a variant who show the associated features, interpreted in context such as age.
Study this concept in context
04 · Genes and Environment: Why People Differ
Relatives may resemble one another and share a history of illness, yet their health can follow different paths. Understanding why requires us to distinguish DNA sequence, gene expression, environmental influences, and the probability of disease.
59 · Preconception health and genetic risk
Preconception care addresses changeable health conditions alongside genetic uncertainty. It supports informed choices without promising zero risk or demanding perfection.
Sources
- NHGRI: Gene Expression
- NHGRI: Mutation
- MedlinePlus Genetics: Phenylketonuria
- MedlinePlus Genetics: Complex Disorders
- MedlinePlus Genetics: Penetrance and expressivity
- NHGRI: Epigenomics Fact Sheet
Definitions come from the published lessons. Read the linked lesson for mechanisms, conditions and examples.